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A Review on Mechanical Behavior of Cryogels and Its Use in Tissue Engineering

Anita Rangra, Shalini Soni


Macroporous hydrogels, which are formed below the freezing point of the solvent, are called cryogels. Due to their enormous properties, they gained significant interest in the fields of tissue engineering. Moderately frozen solutions of monomeric or polymeric precursor are the major site for the formation of cryogels. A large number of macropores are interconnected in cryogels; these pores are also called as supermacropores. Supermacropores allow diffusion of solutes of practically any size, as well as mass transport of nanoparticles and even microparticles without any hindrance. Due to its macroporous structure and durability, cross-linking of gel precursors with each other under a controlled freeze/thaw cycle provides a unique, sponge-like structure called cryogel. In tissue engineering, there are a number of applications for which cryogels are used like in bioreactor systems, cell separation and scaffolding.

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